Saikosaponin D Ameliorates Mechanical Hypersensitivity in Animal Models of Neuropathic Pain
نویسندگان
چکیده
منابع مشابه
Animal models of neuropathic pain.
Animal models are pivotal for understanding the mechanism of neuropathic pain and development of effective therapy for its optimal management. A battery of neuropathic pain models has been developed to simulate the clinical pain conditions with diverse etiology. The present review exhaustively discusses the methodology, behavioral alterations, limitations, and advantages of about 40 different a...
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▼ Diabetic neuropathy is a common complication of diabetes. It occurs in approximately 10–20 % of patients with diabetes, or roughly 40–50 % patients with diabetic neuropathy. However, the pathogenesis of diabetic neuropathic pain is still largely unknown. Several animal models have been used to study the underlying mechanisms for this complication. Some commonly used animal models include stre...
متن کاملAnimal models of diabetic neuropathic pain.
Diabetic neuropathy is a common complication of diabetes. It occurs in approximately 10-20% of patients with diabetes, or roughly 40-50% patients with diabetic neuropathy. However, the pathogenesis of diabetic neuropathic pain is still largely unknown. Several animal models have been used to study the underlying mechanisms for this complication. Some commonly used animal models include streptoz...
متن کاملAnimal Models of Diabetic Neuropathic Pain
▼ Diabetic neuropathy is a common complication of diabetes. It occurs in approximately 10–20 % of patients with diabetes, or roughly 40–50 % patients with diabetic neuropathy. However, the pathogenesis of diabetic neuropathic pain is still largely unknown. Several animal models have been used to study the underlying mechanisms for this complication. Some commonly used animal models include stre...
متن کاملThe GlyT1 Inhibitor Bitopertin Ameliorates Allodynia and Hyperalgesia in Animal Models of Neuropathic and Inflammatory Pain
Background: Chronic pain conditions are difficult to treat and the therapeutic outcome is frequently unsatisfactory. Changes in excitation/inhibition balance within the dorsal horn contribute to the establishment and persistence of chronic pain. Thus, facilitation of inhibitory neurotransmission is a promising approach to treat chronic pain pharmacologically. Glycine transporter 1 (GlyT1) plays...
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ژورنال
عنوان ژورنال: Planta Medica International Open
سال: 2020
ISSN: 2509-9264,2509-6656
DOI: 10.1055/a-1302-4570